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Effects of synbiotic supplementation on the components of metabolic syndrome in military personnel: a double-blind randomised controlled trial
  1. Karim Parastouei1,
  2. S Saeidipoor2,
  3. M Sepandi1,
  4. S Abbaszadeh1 and
  5. M Taghdir1,2
  1. 1Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2Department of Nutrition and Food Hygiene, Faculty of Health, Baqiyatallah University of Medical Sciences, Tehran, Iran
  1. Correspondence to Dr M Taghdir, Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran 143591-13189, Iran; mtaghdir{at}bmsu.ac.ir

Abstract

Introduction Metabolic syndrome comprises a set of risk factors for chronic diseases including abdominal obesity, increased fasting blood glucose (FBG), altered lipid profile and elevated blood pressure (BP). Due to high prevalence of metabolic syndrome and its complications in the military personnel, the relevant problems should be identified and controlled. Therefore, the present study was conducted to determine the effect of synbiotic supplements on the components of metabolic syndrome in the military personnel with metabolic syndrome.

Methodology Sixty military personnel with metabolic syndrome were included in this double-blind randomised controlled clinical trial. During the intervention, they were asked to consume one capsule of synbiotic supplement or placebo per day for 8 weeks. Body Mass Index (BMI), waist circumference, BP, FBG and lipid profile were measured before and after the intervention.

Results The results of the study showed that the synbiotic supplementation had a large significant adjusted effect on the BMI (Cohen’s d=0.82 (95% CI 0.29 to 1.34)). It also had a medium significant adjusted effect on the FBG (Cohen’s d=0.52 (95% CI 0.004 to 1.03)) as well as triglyceride (Cohen’s d=0.65 (95% CI 0.13 to 1.17)).

Conclusion Findings of the study revealed that synbiotic supplementation may lead to a significant improvement in the BMI, triglyceride and FBG levels in the military personnel. Thus, consumption of synbiotic supplements is recommended as an adjuvant therapy in the military personnel with metabolic syndrome.

  • diabetes & endocrinology
  • lipid disorders
  • nutrition & dietetics
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Footnotes

  • Contributors KP, SS, MS, MT and SA studied concept and designed the study. KP, SS and MT collected of data. KP, SS, MS, MT and SA analysed and interpreted of data. MT drafted of the manuscript. KP, SS, MS, MT and SA revised the manuscript. All authors read and approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Prior to starting the research, the objectives and stages of the study were explained to the participants and informed consent was obtained in writing. The study was approved by the Ethics Committee for Research at Baqiyatallah University of Medical Sciences (IR.Bmsu.REC.1397.148) and the Iranian Registry of Clinical Trials (IRCT) (IRCT20140502017522N3).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request.

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