Footnotes

• YW, JN, WM and HZ are joint first authors.

• Contributors Conception and design: YW, SC, KW and MC. Administrative support: YW, JN, WM and HZ. Provision of study materials or patients: YW, WM, LY and TZ. Collection and assembly of data: YW and KW. Data analysis and interpretation: YW, JN, WM and KW. Manuscript writing: YW, JN, WM and HZ. Final approval of manuscript: all authors. YW is responsible for the overall content as guarantor.

• Funding This study was funded by Natural Science Foundation of Jiangsu Province (BK20201271); Innovative Team of Jiangsu Province (2017ZXKJQW07); Jiangsu Provincial Key Research and Development Program (BE2019751); National Natural Science Foundation of China (82070773); The National Key Research and Development Program of China (SQ2017YFSF090096).

• Competing interests None declared.

• Provenance and peer review Not commissioned; externally peer reviewed.

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