RT Journal Article SR Electronic T1 TBI—the most complex disease in the most complex organ: the CENTER-TBI trial—a commentary JF Journal of the Royal Army Medical Corps JO J R Army Med Corps FD British Medical Journal Publishing Group SP 87 OP 89 DO 10.1136/jramc-2015-000472 VO 162 IS 2 A1 Joanna L C Wheble A1 D K Menon YR 2016 UL http://militaryhealth.bmj.com/content/162/2/87.abstract AB Each year, approximately 2.5 million people experience some form of traumatic brain injury (TBI) in Europe. One million of these are admitted to hospital and 75 000 will die. TBI represents a major cause of death and disability, particularly among those of working age. Substantial investments have been made in an effort to improve diagnosis, management and survival in TBI, but with little success. The Collaborative European Neuro-Trauma Effectiveness Research in TBI (CENTER-TBI) study promises to use the natural variability seen in the management of TBI across Europe with the application of Comparative Effectiveness Research (CER). It will generate repositories of baseline and comprehensive TBI patient data, neuroimaging, neurogenetics and biomarkers, which aim to improve the diagnosis, stratification, management and prognostication of patients with TBI.