Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology
ReviewOrgan arrest, protection and preservation: natural hibernation to cardiac surgery☆
Section snippets
Foreword
Peter Hochachka was inspirational as a scientist and as a person. I will always cherish his infectious enthusiasm for science, his keen sense of humour, and his tireless search for the unifying concepts that underpin the spectacular diversity of life. Many of these concepts, and other ‘news and views’ stories in science, were topics of lively discussions with Peter during the lab's morning and afternoon walks to the University of British Columbia's (UBC) Faculty club for tea or coffee. It was
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Cited by (49)
Down regulation of sodium channels in the central nervous system of hibernating snails
2014, Physiology and BehaviorCitation Excerpt :This decreased metabolic rate is the main strategy for invertebrate and vertebrate animals to overcome unfavorable environmental conditions such as anoxia, estivation and hibernation [1,2]. It is suggested that such an entropy-slowing strategy increases the survival potential of different species and developed during evolution [3]. Although the mechanisms of survival are known to include changes in the monoamine content, large stores of glycogen and drastically decreased metabolism [4,5], other mechanisms, such as the release of inhibitory transmitter, changes in peptide–protein profile and regulation of ion channel expression in excitable membranes have also been demonstrated or hypothesized [6–10].
Hemodynamic rescue and ECG stability during chest compressions using adenosine and lidocaine after 8-minute asphyxial hypoxia in the rat
2013, American Journal of Emergency MedicineCitation Excerpt :The objective of our study was to investigate the effect of 0.5 mL bolus of adenosine and lidocaine (AL) on rescue hemodynamics and electrocardiogram (ECG) stability during chest compressions after 8-minute asphyxial hypoxia in the rat. Previously, we and others have reported that AL at high concentrations arrests the heart in a polarized state, and at lower concentrations, it resuscitates the heart for reanimation [10-12]. At these lower concentrations, AL with Mg2 + (ALM) also resuscitates and stabilizes the heart after severe-to-extreme hemorrhagic shock [13,14], and it exerts potent anti-inflammatory properties [15] and fully corrects acute traumatic coagulopathy [16].
Eight hours of cold static storage with adenosine and lidocaine (Adenocaine) heart preservation solutions: Toward therapeutic suspended animation
2011, Journal of Thoracic and Cardiovascular SurgeryReactive oxygen species: Role in obesity and mitochondrial energy efficiency
2023, Philosophical Transactions of the Royal Society B: Biological SciencesWhy are bleeding trauma patients still dying? Towards a systems hypothesis of trauma
2022, Frontiers in Physiology
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The papers in this volume are dedicated to the memory of our friend and mentor, Peter W. Hochachka, whose intelligence, curiosity, enthusiasm, and encouragement catalyzed research in diverse areas of comparative physiology and biochemistry and taught us that following one's curiosity in science can be both productive and fun.