User profiles for "author:A Franke"
Andre FrankeProfessor for Molecular Medicine, Christian-Albrechts-University of Kiel Verified email at mucosa.de Cited by 92750 |
Microbial exposure during early life has persistent effects on natural killer T cell function
Exposure to microbes during early childhood is associated with protection from immune-
mediated diseases such as inflammatory bowel disease (IBD) and asthma. Here, we show …
mediated diseases such as inflammatory bowel disease (IBD) and asthma. Here, we show …
[HTML][HTML] Reporting guidelines for human microbiome research: the STORMS checklist
The particularly interdisciplinary nature of human microbiome research makes the
organization and reporting of results spanning epidemiology, biology, bioinformatics …
organization and reporting of results spanning epidemiology, biology, bioinformatics …
Targeted enrichment of genomic DNA regions for next-generation sequencing
…, PJ Van Der Zaag, A Franke… - Briefings in …, 2011 - academic.oup.com
In this review, we discuss the latest targeted enrichment methods and aspects of their
utilization along with second-generation sequencing for complex genome analysis. In doing …
utilization along with second-generation sequencing for complex genome analysis. In doing …
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
…, JC Barrett, A Franke… - Nature …, 2015 - nature.com
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis …
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis …
Indication of Reactor Disappearance in the Double Chooz Experiment
Abstract The Double Chooz experiment presents an indication of reactor electron
antineutrino disappearance consistent with neutrino oscillations. An observed-to-predicted …
antineutrino disappearance consistent with neutrino oscillations. An observed-to-predicted …
Large-scale association analyses identify host factors influencing human gut microbiome composition
…, AG Uitterlinden, F Rivadeneira, A Franke… - Nature …, 2021 - nature.com
To study the effect of host genetics on gut microbiome composition, the MiBioGen
consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data …
consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data …
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735
individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were …
individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were …