User profiles for "author:A Franke"

Andre Franke

Professor for Molecular Medicine, Christian-Albrechts-University of Kiel
Verified email at mucosa.de
Cited by 92750

Microbial exposure during early life has persistent effects on natural killer T cell function

T Olszak, D An, S Zeissig, MP Vera, J Richter, A Franke… - Science, 2012 - science.org
Exposure to microbes during early childhood is associated with protection from immune-
mediated diseases such as inflammatory bowel disease (IBD) and asthma. Here, we show …

[HTML][HTML] Reporting guidelines for human microbiome research: the STORMS checklist

…, J Fettweis, RD Finn, AA Fodor, S Forslund, A Franke… - Nature medicine, 2021 - nature.com
The particularly interdisciplinary nature of human microbiome research makes the
organization and reporting of results spanning epidemiology, biology, bioinformatics …

Targeted enrichment of genomic DNA regions for next-generation sequencing

…, PJ Van Der Zaag, A Franke… - Briefings in …, 2011 - academic.oup.com
In this review, we discuss the latest targeted enrichment methods and aspects of their
utilization along with second-generation sequencing for complex genome analysis. In doing …

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

…, CG Mathew, JD Rioux, EE Schadt, MJ Daly, A Franke… - Nature, 2012 - nature.com
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

A Franke, DPB McGovern, JC Barrett, K Wang… - Nature …, 2010 - nature.com
We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

…, JC Barrett, A Franke… - Nature …, 2015 - nature.com
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

CA Anderson, G Boucher, CW Lees, A Franke… - Nature …, 2011 - nature.com
Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis …

Indication of Reactor Disappearance in the Double Chooz Experiment

Y Abe, C Aberle, T Akiri, JC Dos Anjos, F Ardellier… - Physical Review Letters, 2012 - APS
Abstract The Double Chooz experiment presents an indication of reactor electron
antineutrino disappearance consistent with neutrino oscillations. An observed-to-predicted …

Large-scale association analyses identify host factors influencing human gut microbiome composition

…, AG Uitterlinden, F Rivadeneira, A Franke… - Nature …, 2021 - nature.com
To study the effect of host genetics on gut microbiome composition, the MiBioGen
consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data …

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

J Hampe, A Franke, P Rosenstiel, A Till, M Teuber… - Nature …, 2007 - nature.com
We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735
individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were …