Patients with pancreatic cancer frequently develop the syndrome of cancer cachexia. Pro‐
inflammatory cytokines have been strongly implicated in the pathogenesis of this syndrome …

Liver diseases are of major concern as they now account for millions of deaths annually. As
a result of the increased incidence of liver disease, many patients die on the transplant …

Research into the hypoxic tumour microenvironment is accelerating and the reversal of
hypoxia is increasingly being suggested as a mechanism for improving cancer treatment …

The potential to differentiate human embryonic stem cells (hESCs) in vitro to provide an
unlimited source of human hepatocytes for use in biomedical research, drug discovery, and …

Human embryonic stem cells (hESCs) are a valuable source of pluripotential primary cells.
To date, however, their homogeneous cellular differentiation to specific cell types in vitro has …

With the advent of induced pluripotent stem cell (iPSC) technology, it is now feasible to
generate iPSCs with a defined genotype or disease state. When coupled with direct …

Objective: To determine whether resting energy expenditure (REE) is increased in cachectic
patients with pancreatic cancer and to define the relation of tumor necrosis factor (TNF) and …

Background. Current methods to predict survival duration of patients with pancreatic cancer
are limited. The aim of this study was to determine whether certain nutritional indices and the …

Cachexia is common in patients with pancreatic cancer and has been associated with
persistent activation of the hepatic acute phase response and increased energy …

Eicosapentaenoic acid (EPA) has been shown to modulate aspects of the inflammatory
response that may contribute to weight loss in cancer. This study aimed to evaluate the …