Effect of various concentrations of antibiotics on osteogenic cell viability and activity

CR Rathbone, JD Cross, KV Brown… - Journal of …, 2011 - Wiley Online Library
Infection is a common complication of open fractures. Systemic antibiotics often cause
adverse events before eradication of infected bone occurs. The local delivery of antibiotics …

High velocity gunshot injuries to the extremities: management on and off the battlefield

JG Penn-Barwell, KV Brown, CA Fries - Current reviews in musculoskeletal …, 2015 - Springer
The gunshot wounds sustained on the battlefield caused by military ammunition can be
different in nature to those usually encountered in the civilian setting. The main difference is …

Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model

B Li, KV Brown, JC Wenke, SA Guelcher - Journal of Controlled Release, 2010 - Elsevier
Infection is a common complication in open fractures that compromises the healing of bone
and can result in loss of limb or life. Currently, the clinical standard of care for treating …

Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release

KV Brown, B Li, T Guda, DS Perrien… - … Engineering Part A, 2011 - liebertpub.com
Nonunion is a common complication in open fractures and other severe bone injuries.
Recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered on a collagen …

Predicting the need for early amputation in ballistic mangled extremity injuries

KV Brown, A Ramasamy, J McLeod… - Journal of Trauma …, 2009 - journals.lww.com
Background: Despite modern advances, amputation is still a commonly performed operation
in war. It is often difficult to decide whether to amputate after high-energy trauma to the lower …

Infectious complications of combat-related mangled extremity injuries in the British military

KV Brown, CK Murray, JC Clasper - Journal of Trauma and Acute …, 2010 - journals.lww.com
Background: During the wars in Iraq and Afghanistan, extremity injuries have predominated;
however, no systematic review of field and stabilization care with subsequent infectious …

Dual-purpose bone grafts improve healing and reduce infection

SA Guelcher, KV Brown, B Li, T Guda… - … of orthopaedic trauma, 2011 - journals.lww.com
Objective: To determine if a dual-purpose bone graft can regenerate bone and reduce
infection in highly contaminated bone critical size defects in rats. Methods: Biodegradable …

Comparison of development of heterotopic ossification in injured US and UK Armed Services personnel with combat-related amputations: preliminary findings and …

KV Brown, S Dharm-Datta, BK Potter… - Journal of Trauma …, 2010 - journals.lww.com
Background: Recent reports have documented the rate of heterotopic ossification (HO)
formation in the residual limbs of combat-related amputees from the US Armed Forces …

Earlier debridement and antibiotic administration decrease infection

KV Brown, JA Walker, DS Cortez, CK Murray… - Journal of surgical …, 2010 - apps.dtic.mil
Timing of debridement and local antibiotic administration on infection has not been clearly
defined. A contaminated critical size rat femur defect model was used to determine if earlier …

Complications of extremity vascular injuries in conflict

KV Brown, A Ramasamy, N Tai… - Journal of Trauma …, 2009 - journals.lww.com
Aim: The purpose of this study was to study the complication rate after extremity vascular
injury. In particular, the aim was to analyze whether this was influenced by the presence or …