The hippocampal formation has been implicated in a growing number of disorders, from
Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the …

Epidemiological studies have shown a clear association between maternal infection and
schizophrenia or autism in the progeny. Animal models have revealed maternal immune …

Scientists have long sought to characterize the pathophysiologic basis of schizophrenia and
develop biomarkers that could identify the illness. Extensive postmortem and in vivo …

African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-
Saharan Africa. We present the sequence and analysis of the 11 megabase-sized …

Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of
millions of people in the developing world. We have sequenced the∼ 90 megabase (Mb) …

The flowering plant Arabidopsis thaliana is a dicot model organism for research in many
aspects of plant biology. A comprehensive annotation of its genome paves the way for …

Background Huntington's disease is an autosomal-dominant neurodegenerative disease
caused by CAG trinucleotide repeat expansion in HTT, resulting in a mutant huntingtin …

The hippocampus in schizophrenia is characterized by both hypermetabolism and reduced
size. It remains unknown whether these abnormalities are mechanistically linked. Here we …

Context Because schizophrenia and related disorders have a chronic time course and
subtle histopathology, it is difficult to identify which brain regions are differentially targeted …

The current research paradigm for Huntington's disease is based on participants with overt
clinical phenotypes and does not address its pathophysiology nor the biomarker changes …