Mechanisms of fibrosis: therapeutic translation for fibrotic disease

TA Wynn, TR Ramalingam - Nature medicine, 2012 - nature.com
Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or
scarring, is defined by the accumulation of excess extracellular matrix components. If highly …

Immunopathology of schistosomiasis

MS Wilson, MM Mentink‐Kane, JT Pesce… - Immunology and cell …, 2007 - Wiley Online Library
Waterborne parasitic diseases plague tropical regions of the world with the development of
water resources often increasing transmission. Skin‐penetrating cercariae (infectious stages …

[HTML][HTML] Arginase-1–expressing macrophages suppress Th2 cytokine–driven inflammation and fibrosis

JT Pesce, TR Ramalingam, MM Mentink-Kane… - PLoS …, 2009 - journals.plos.org
Macrophage-specific expression of Arginase-1 is commonly believed to promote
inflammation, fibrosis, and wound healing by enhancing L-proline, polyamine, and Th2 …

[PDF][PDF] CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin

S Basu, RJ Binder, T Ramalingam, PK Srivastava - Immunity, 2001 - cell.com
Complexes of the heat shock protein gp96 and antigenic peptides are taken up by antigen-
presenting cells and presented by MHC class I molecules. In order to explain the unusual …

Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

MS Wilson, SK Madala, TR Ramalingam… - Journal of Experimental …, 2010 - rupress.org
Idiopathic pulmonary fibrosis (IPF) is a destructive inflammatory disease with limited
therapeutic options. To better understand the inflammatory responses that precede and …

Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity

SP Spencer, C Wilhelm, Q Yang, JA Hall, N Bouladoux… - Science, 2014 - science.org
How the immune system adapts to malnutrition to sustain immunity at barrier surfaces, such
as the intestine, remains unclear. Vitamin A deficiency is one of the most common …

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma

DF Choy, KM Hart, LA Borthwick, A Shikotra… - Science translational …, 2015 - science.org
Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct
molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n= 51) …

[HTML][HTML] The IL-21 receptor augments Th2 effector function and alternative macrophage activation

J Pesce, M Kaviratne, TR Ramalingam… - The Journal of …, 2006 - Am Soc Clin Investig
The IL-21 receptor (IL-21R) shows significant homology with the IL-4R, and CD4+ Th2 cells
are an important source of IL-21. Here we examined whether the IL-21R regulates the …

Mechanisms controlling normal defecation and the potential effects of spinal cord injury

AF Brading, T Ramalingam - Progress in brain research, 2006 - Elsevier
Spinal cord injury frequently leads to bowel dysfunction with the result that emptying the
bowel can occupy a significant part of the day and reduce the quality of life. This chapter …

[HTML][HTML] Retnla (Relmα/Fizz1) suppresses helminth-induced Th2-type immunity

JT Pesce, TR Ramalingam, MS Wilson… - PLoS …, 2009 - journals.plos.org
Retnla (Resistin-like molecule alpha/FIZZ1) is induced during Th2 cytokine immune
responses. However, the role of Retnla in Th2-type immunity is unknown. Here, using …